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Principles of pharmacogenetics and pharmacogenomics pdf


principles of pharmacogenetics and pharmacogenomics pdf

By understanding the god of war full hd photo variations in the genetic makeup of pashto keyboard for ipad an individual, it becomes easy for a clinician to select the appropriate drug at the appropriate dose.
Conclusion, many prescribed drugs either dont produce the desired therapeutic effect or have extensive undesired effects.
This led to the vision of "personalized medicine that is, making drug use more effective and safer by giving drugs that fit a person's genes.5 As the initial draft of human genome has revealed, there are over.4 million single nucleotide polymorphisms (snps) in the.The authors also highlight the future benefits, barriers and ethical considerations associated with pharmacogenomics.Dube subish palaian P ravi shankar P prabhu M bista D khadka chhetri A, mishra P 1,2.Similarly, the pharmacotherapy of common diseases like asthma, hypertension, depression etc is also influenced by genetic variations.However, factors such as affordability, ease of application, and ease of interpreting the results play a vital role in extrapolating the pharmacogenomic data to personalized medicine).Abstract, the genetic makeup affects drug responses to a greater extend.
Safety and efficacy of many commonly prescribed drugs like aspirin, isoniazid, omeprazole, warfarin, hydralazine etc are affected by the genetic makeup of individuals.
Genetic make up is thus one of the commonest factors affecting the drug response.The ESF-UB Conference on Pharmacogenomics will concentrate on adverse drug reactions this year, providing an interactive forum for both senior and junior researchers to learn about the latest developments in safety pharmacogenomics.Correspondence Address : bish.Understanding THE essentials OF pharmacogenomics- THE potential implications FOR THE future pharmacotherapy.There is an urgent need to develop strategies to reduce the burden of adverse drug reaction this needs to apply to both drug development (to reduce the rate of attrition) and during clinical use (to reduce patient morbidity, mortality, costs to healthcare, and drug withdrawals). .




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